| 细胞色素P450 2D6缺陷型等位基因的家系分析 |
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| 引用本文： | 陈枢青,孙红颖,赵鲁杭,Peter J WedlundCHEN Shu-qing,SUN Hong-ying,ZHAO Lu-hang Peter J Wedlund.细胞色素P450 2D6缺陷型等位基因的家系分析[J].遗传,1998,20(5):28-30. |
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| 作者姓名： | 陈枢青 孙红颖 赵鲁杭 Peter J WedlundCHEN Shu-qing SUN Hong-ying ZHAO Lu-hang Peter J Wedlund |
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| 作者单位： | 1.浙江医科大学生物化学教研室, 浙江 310006
2.美国肯塔基大学药学院，列克星敦 KY40536
1.Department of Biochemistry,Zhejiang Medical University,Hangzhou 310006
2.College of Pharmacy,University of Kentucky,Lexington KY40536 USA |
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| 摘 要： | 利用等位基因特民扩增法(ASA)为基础的基因分型法,对细胞色素P4502D6 (CYP2D6)缺陷型等位基因携带者的9个家庭共38个进行了基因分型,并与用右旋美沙芬为
探针的表型分型法进行对比,发现两种方法的结果是一致的,CYP2D6酶缺陷型等位基因呈常染色体隐性遗传。
Abstract:A genotyping method based on the principle of allele-specific amplification and a phenotyping procedure with dextromethorphan as a probe were employed in familial study of nine families with 38 members for the cytochrome P450 2D6(CYP2D6)deficient alleles——CYP2D6A,CYP2D6B,CYP2D6D and CYP2D6T.The results showed that the CYP2D6 deficient alleles were inherited as an autosomal recessive trait.
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| 关 键 词： | 细胞色素P450 2D6 CYP2D6 表型分型 基因分型 家系分析 Key words PCR 克隆 5′调控区 鸡生长激素 |
A Familial Study of Cytochrome P450 2D6(CYP2D6) Deficient Alleles |
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| CHEN Shuqing,SUN Hongying,ZHAO Luhang.A Familial Study of Cytochrome P450 2D6(CYP2D6) Deficient Alleles[J].Hereditas,1998,20(5):28-30. |
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| Authors: | CHEN Shuqing SUN Hongying ZHAO Luhang |
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| Abstract: | |
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| Keywords: | cytochrome P450 2D6 (CYP2D6) Genotyping Phenotyping Familial study |
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