| 偏执型精神分裂症与4个涉及多巴胺代谢的基因之间的关联分析 |
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| 引用本文： | 李俊宁,许琪,沈岩,季梁.偏执型精神分裂症与4个涉及多巴胺代谢的基因之间的关联分析[J].遗传,2006,28(4):403-406. |
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| 作者姓名： | 李俊宁 许琪 沈岩 季梁 |
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| 作者单位： | 1.清华大学生物信息学教育部重点实验室 清华大学自动化系， 北京 100084;
2.中国医学科学院基础医学研究所 中国协和医科大学基础医学院 医学分子生物学国家重点实验室， 北京 100005 |
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| 摘 要： | 精神分裂症是由多基因相互作用导致的复杂疾病。对其易感基因，儿茶酚氧位甲基转移酶基因（COMT）的众多报道充满了矛盾。在对偏执型精神分裂症研究中，我们用多基因座关联分析法研究了4个涉及神经递质多巴胺代谢的基因之间的相互作用。分析结果支持如下假说：COMT-136-BclI对Val108/158Met有调控作用。当前者的基因型是CC时，后者的易感等位基因型是Met（A）；而当前者的基因型是GG时，后者的易感等位基因型是Val（G）。这一新的假说可以解释此前单基因座分析对Val108/158Met(COMT)的截然相反的报道，同时也显示了多基因座分析对复杂疾病研究的必要性。
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| 关 键 词： | 偏执型精神分裂症 儿茶酚氧位甲基转移酶基因 多基因座关联分析 |
| 文章编号： | 0253-9772(2006)04-0403-04 |
| 收稿时间： | 2005-05-17 |
| 修稿时间： | 2005-07-08 |
An Association Study Between Paranoid Schizophrenia and Four Genes Involved in Dopamine Metabolism |
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| LI Jun-Ning,XU Qi,SHEN Yan,JI Liang.An Association Study Between Paranoid Schizophrenia and Four Genes Involved in Dopamine Metabolism[J].Hereditas,2006,28(4):403-406. |
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| Authors: | LI Jun-Ning XU Qi SHEN Yan JI Liang |
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| Institution: | 1.The MOE Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing 100084, China;2.National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China |
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| Abstract: | Schizophrenia is a complex disease caused by interactions among multiple genes. Reports of one of its susceptibility genes, ethyltracatechol-O-mnsferase (COMT) have been conflicting. In the present study on paranoid schizophrenia, we have performed a multilocus association study to analyze the interactions among 4 genes that are involved in dopamine metabolism. Result supports the hypothesis that COMT-136-BclI regulates Val108/158Met. When the genotype of the former is CC, Met (A) is the genotype of susceptibility allele Val108/158Met; and when the genotype of the former is GG, Val (G) is the genotype of susceptibility allele Val108/158Met. This new hypothesis may explain the conflicting results about Val108/158Met (COMT) obtained by single-locus analyses. It also illustrates that multilocus analysis is necessary for the research of complex diseases. |
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| Keywords: | paranoid schizophrenia catechol-O-methyltransferase multilocus association study |
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