| 多巴胺D4受体基因与注意缺损多动障碍 |
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| 引用本文： | 张野,忻仁娥,江三多,汤国梅,钱伊萍,李飞,汪栋祥.多巴胺D4受体基因与注意缺损多动障碍[J].遗传,2001,23(5):413-414. |
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| 作者姓名： | 张野 忻仁娥 江三多 汤国梅 钱伊萍 李飞 汪栋祥 |
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| 作者单位： | 上海市精神卫生中心 |
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| 摘 要： | 为探讨注意缺损多动障碍（ADHD）与多巴胺D4受体基因（dopamine D4 receptor gene,DRD4)间的关系，采用Amp-FLP的方法检测了上海地区汉族人群中68例ADHD患及其父母DRD4的多态性，数据采用基于单体型的单体型相对风险（HHRR）及传递不平衡检验（TDT）进行遗传关联分析。结果表明HHRR分析和复等位基因的TDT检验，均未显示出与ADHD的遗传关联性（P＞0．05）。提示上海地区人群中DRD4基因与ADHD无显性关联。
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| 关 键 词： | 注意缺损多动障碍 多巴胺D4受体基因 单体型相对风险 传递不平衡检验 |
| 文章编号： | 0253-9772(2001)05-0413-02 |
| 修稿时间： | 2001年4月20日 |
The Association Between Attention-deficit Hyperactivity Disorder and Dopamine Receptor D4 Gene |
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| ZHANG Ye,XIN Ren er,JIANG San duo,TANG Guo mei,QIN Yi ping,LI Fei,WANG Dong xiang.The Association Between Attention-deficit Hyperactivity Disorder and Dopamine Receptor D4 Gene[J].Hereditas,2001,23(5):413-414. |
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| Authors: | ZHANG Ye XIN Ren er JIANG San duo TANG Guo mei QIN Yi ping LI Fei WANG Dong xiang |
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| Abstract: | The present study was designed to investigate the association between attention-deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene( DRD4 ).Amp-FLP was used to test the polymorphisms of DRD4 in 68 ADHD children and their parents from Shanghai.The haplotype-based haplotype relative risk( HHRR ) and transmission disequilibrium test ( TDT ) methods were used to analyze the association between DRD4 and ADHD.In our samples we found no significant association between DRD4 and ADHD ( P >0.05).Our results do not support that ADHD is associated with DRD4 in population in Shanghai. |
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| Keywords: | ADHD dopamine D4 receptor gene( DRD4 ) haplotype-based haplotype relative risk transmission disequilibrium test |
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