| 哺乳动物中的DNA主动去甲基化 |
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| 作者姓名： | Xiao Y Zhang HL Bai LY Wang XM Li WG Yang LG |
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| 作者单位： | 华中农业大学动物科技学院,农业动物遗传育种与繁殖教育部重点实验室,武汉,430070 |
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| 基金项目： | 国家现代农业技术体系项目,国家自然科学基金项目 |
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| 摘 要： | DNA甲基化是一种相对稳定且可遗传的表观遗传标记,在植物和动物细胞中均发现有DNA主动去甲基化现象,其机制在植物中已基本得到阐释,但在哺乳动物中尚未鉴定出一种有效的DNA去甲基化酶,并且DNA主动去甲基化途径也存在争议。文章综合分析了近期的文献资料,阐述了哺乳动物中发生DNA主动去甲基化的时空特异性,并从细胞和组织特异性角度介绍DNA主动去甲基化的可能通路和机制,即5-甲基胞嘧啶的氧化作用、5-甲基胞嘧啶脱氨基以及DNA修复等,旨在为破译表观遗传重编程过程提供理论依据。
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| 关 键 词： | DNA去甲基化 细胞重编程 活化诱导的胞嘧啶脱氨酶 DNA修复 |
Active DNA demethylation in mammals |
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| Xiao Y,Zhang HL,Bai LY,Wang XM,Li WG,Yang LG.Active DNA demethylation in mammals[J].Hereditas,2011,33(4):298-306. |
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| Authors: | Xiao Yao Zhang Hua-Lin Bai Li-Ya Wang Xiao-Ming Li Wen-Gong Yang Li-Guo |
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| Institution: | XIAO Yao,ZHANG Hua-Lin,BAI Li-Ya,WANG Xiao-Ming,LI Wen-Gong,YANG Li-Guo Key Lab of Education Ministry of China in Agricultural Animal Genetics,Breeding and Reproduction,College of Animal Science and Technology,Huazhong Agricultural University,Wuhan 430070,China |
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| Abstract: | DNA methylation is a stable and heritable epigenetic mark,and it is one of the best characterized epigenetic modifications.Active DNA demethylation has been reported both in plant and animal cells,and the mechanism behind it is becoming clear in plant.Whereas a bona fide enzyme,which is responsible for active DNA demethylation,have not been identified in mammals,and active demethylation pathway is controversial.In the present review,we described that active DNA demethylation take place in a spatial-and temp... |
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| Keywords: | DNA demethylation cell reprogramming AID DNA repair |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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