| 云南人群系统性红斑狼疮与TNF微卫星基因座关系的研究 |
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| 引用本文： | 初正韬,孙浩,钱亚屏,史磊,俞建昆,褚嘉祐.云南人群系统性红斑狼疮与TNF微卫星基因座关系的研究[J].遗传,2001,23(1):11-13. |
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| 作者姓名： | 初正韬 孙浩 钱亚屏 史磊 俞建昆 褚嘉祐 |
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| 作者单位： | 中国协和医科大学中国医学科学院医学生物学研究所, |
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| 基金项目： | 国家自然科学基金重大项目(39993420)、美国中华医学基金CMB(98-675)和云南省应用基础基金(1999C0025Q)资助项目 |
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| 摘 要： | 位于MHC内的肿瘤坏死因子（tomor necrosis factor,TNF)基因区域有5个微卫星基因座a、b、c、d和e，本研究调查了中国云南汉族系统性红斑狼疮（systemic lupus erythematosus,SLE）与这几个微卫星基因座多态性的关系。本用荧光标记引物和半自动基因扫描方法对云南地区97例SLE患及79例健康对照的5个微卫星基因座进行了基因分型，结果发现，SLE患的TNFα1（P＝0.0206），c2（P＝0.0000)等位基因频率较正常人显增高，而TNFα2(P=0.01630，c3(P=0.0065),c4(p=0.0012),d6(P=0.0448）等位基因频率则是正常对照较SLE患高。同时我们还发现在这5个微卫星基因座中，与白种人比较中国人出现了尚未发现的新等位基因。
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| 关 键 词： | SLE TNF 微卫星基因座 基因扫描 云南 系统性红斑狼疮 |
| 文章编号： | 0253-9772(2001)01-0011-03 |
| 修稿时间： | 2000年4月21日 |
The Relation Between TNF
Microsatellite Loci Polymorphism and Systemic Lupus Erythematosus in Yunnan People |
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| CHU Zheng-Tao,SUN Hao,QIAN Ya-Ping,SHI Lei,YU Jian-kun,CHU Jia-You.The Relation Between TNF
Microsatellite Loci Polymorphism and Systemic Lupus Erythematosus in Yunnan People[J].Hereditas,2001,23(1):11-13. |
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| Authors: | CHU Zheng-Tao SUN Hao QIAN Ya-Ping SHI Lei YU Jian-kun CHU Jia-You |
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| Abstract: | We have investigated TNF microsatellite polymorphism in SLE A total of 97 Chinese Han SLE patients and 79 matched Chinese Han controls were studied in this study, TNF microsatellites a,b,c,d and e were typed using fluorescent labeled automated genescanning and genotyping TNFa1(P =0 0206), c2 (P =0 0000) allele frequencies were significantly increased in the SLE group comparing with controls,and TNF a2 (P=0 0163) c3(P=0 0065),c4(P=0 0012),d6(P =0 0448) allele frequencies were significantly increased in controls Meanwhile,we found some new alleles in Chinese which are different form those in Caucasoids. |
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| Keywords: | SLE TNF microsatellite loci genes canning |
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