| 动物季节性繁殖分子调控机理研究进展 |
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| 作者姓名： | Huang DW Chu MX |
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| 作者单位： | 中国农业科学院北京畜牧兽医研究所,农业部畜禽遗传资源与利用重点开放实验室,北京100193 |
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| 基金项目： | 国家现代农业产业技术体系建设专项资金,国家863计划,国家973计划,国家科技支撑计划,国家自然科学基金项目,中国农业科学院首批优秀科技创新团队专项资助 |
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| 摘 要： | 动物季节性发情繁殖涉及下丘脑-垂体-性腺轴系统复杂的神经内分泌过程,并受光照周期等环境因素的影响。褪黑激素则作为光周期信号分子调控动物季节性繁殖活动。近年来研究发现,对GnRH分泌有重要影响的Kiss1/GPR54系统既受褪黑激素的调控又受到性腺类固醇激素反馈调节,Kiss1/GPR54系统很可能是调控动物季节性繁殖的关键因子;同时动物季节性繁殖很可能还存在一条涉及TSH-DIO2/DIO3系统的逆向调控通路,该系统同样显著影响GnRH合成释放并受褪黑激素调控。文章就褪黑激素中心信号,特别是Kiss1/GPR54和TSH-DIO2/DIO3系统对繁殖季节性调控的最新研究进展进行综述。
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| 关 键 词： | 季节性繁殖 分子调控 褪黑激素 Kiss1 促甲状腺素 |
Research progress in molecular mechanism of animal seasonal reproduction |
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| Huang DW,Chu MX.Research progress in molecular mechanism of animal seasonal reproduction[J].Hereditas,2011,33(7):695-706. |
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| Authors: | Huang Dong-Wei Chu Ming-Xing |
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| Institution: | HUANG Dong-Wei,CHU Ming-Xing Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture,Institute of Animal Science,Chinese Acad-emy of Agricultural Sciences,Beijing 100193,China |
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| Abstract: | Animal seasonal reproduction involves complicated neuroendocrine processes of the hypothalamo-pi-tuitary-gonadal axis.It is dominantly regulated by photoperiod,a crucial environmental cue.Melatonin,as internal photo-period signal,regulates seasonal reproduction of animals.In recent years,it has been found that Kiss1/GPR54 system,which may influence GnRH secretion evidently,is regulated by both melatonin and feedback action of gonadal steroid hormones.Consequently,Kiss1/GPR54 system may play a key role in se... |
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| Keywords: | Kiss1 |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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