| 果蝇DNA甲基化研究进展 |
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| 作者姓名： | Guo XX Ye HY Zhang M |
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| 作者单位： | 陕西师范大学生命科学学院,西安,710062 |
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| 基金项目： | 中央高校基本科研业务费专项资金,和陕西省自然科学基金项目 |
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| 摘 要： | DNA甲基化是表观遗传调控的重要机制,但果蝇很久以来被认为是一种缺乏甲基化的模式生物。近年来才证实果蝇基因组中有5′-甲基胞嘧啶残基的存在,其DNA甲基化水平在胚胎发育早期达到最高,总体水平低于脊椎动物及植物。果蝇拥有一个包含dDNMT2和dMBD2/3的简单甲基化修饰系统,其分别与哺乳动物中的DNMT2家族及MBD2/MBD3蛋白高度同源。果蝇DNA甲基化模式和特点可能随果蝇种类不同而不同。文章对果蝇DNA甲基化特点及其功能研究进展进行了综述。
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| 关 键 词： | DNA甲基化 果蝇 甲基化修饰系统 DNA甲基转移酶 |
DNA methylation in Drosophila, a review of recent studies |
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| Guo XX,Ye HY,Zhang M.DNA methylation in Drosophila, a review of recent studies[J].Hereditas,2011,33(7):713-719. |
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| Authors: | Guo Xin-Xin Ye Hai-Yan Zhang Min |
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| Institution: | College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China. guoxinxin@stu.snnu.edu.cn |
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| Abstract: | DNA methylation is a key mechanism underlying epigenetic regulation.Fruit fly has been considered as a free DNA methylation organism until recently a few studies demonstrated that genomic methylated DNA is prevalent during the early embryonic development;but the overall methylation level in Drosophila is lower than in vertebrates and plants.The putative genomic DNA methylation systerm in Drosophila contains a methyltransferase termed dDNMT2 and a methyl-binding protein dMBD2/3.dDNMT2 shows significant homol... |
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| Keywords: | DNA methylatio Drosophila DNA methylation system DNA methyltranferase |
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