基因组内碱基分布整体均衡与局部不均衡的研究进展

近年来，随着各种基因组计划的相继完成，发现在各种生物体单核苷酸链水平上存在着A≌T，G≌C的数量关系，但从几千个至十几万个碱基的范围来看，A≠T，G≠C。从数学上可以证明，如果DNA双链之间碱基的突变率一致，则A≌T，G≌C成立，但很多实验表明，双链之间的突变率并不一致，因此这个问题的解决仍有赖于数理科学和生物学的进一步结合。 Abstract:With more and more genome have been completely sequenced,scientists find the Partial Rule 2(PR2) in entire single strand that A≌T，G≌C.But from the scope of thousands to hundreds of thousand bases,A≠T，G≠C.Form the view of math,if the mutational rate of one strand is equal to others,it could be proved that A≌T，G≌C,but from the view of experience,that premise doesn't exist,so the solution of the problem needs the deeply combination of biology and math.

Advance in the Entire Balance and Local Unbalance of Base Distribution in Genome

With more and more genome have been completely sequenced, scientists find the Partial Rule 2 (PR2) in entire single strand that A approximately equal to T, G approximately equal to C. But from the scope of thousands to hundreds of thousand bases, A not = T, G not = C. From the view of math, if the mutational rate of one strand is equal to others, it could be proved that A approximately equal to T, G approximately equal to C, but from the view of experience, that premise doesn't exist, so the solution of the problem needs the deeply combination of biology and math.