| 脊椎动物多趾性状的研究进展
Progress on Polydactyly Character of Vertebrate |
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| 引用本文： | 黄艳群～,邓学梅,李 宁,邱祥聘 HUANGYan-Qun,,DENG Xue-Mei,LI Ning,QIU Xiang-Pin.脊椎动物多趾性状的研究进展
Progress on Polydactyly Character of Vertebrate[J].遗传,2004,26(3):0. |
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| 作者姓名： | 黄艳群～ 邓学梅 李 宁 邱祥聘 HUANGYan-Qun DENG Xue-Mei LI Ning QIU Xiang-Pin |
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| 作者单位： | 1.中国农业大学国家农业生物技术重点实验室，北京100094；
2.四川农业大学动物科技学院，雅安 625014；3.河南农业大学牧医工程学院，郑州450002 1.State Key National Laboratory of Biotechnology ,China Agricultural University,Beijing,100094 China;
2.College of Animal Science,Sichuan Agricultural University,Ya’an,Sichuan, 625014 China;
3.College of Animal Science,Henan Agricultural University,Zhenzhou,henan ,450002 China |
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| 摘 要： | 多趾是脊椎动物常见的肢体异常，在不同物种间具有相似的表型。研究表明,有相同的基因和发育机理控制不同物种间的多趾表型；最近在人和鼠上的研究进一步表明PPD应是由于干扰了位于Lmbr1内含子内的Shh长程顺式调控元件引起的。对脊椎动物多趾性状的发生机理和相关基因的研究进展进行了综述。Abstract: Polydactyly is a common abnormal limb phenotype in vertebrate and there is similar limb phenotype among different species. Research shows that polydactyly has a similar development mechanism, and this kind of polydactyly character seems to be controlled by homologous genes among species. The latest research results on human and mouse further shows that PPD should be caused by the disruption of a long range cis-acting regulator for Shh within Lmbr1 intron. Here the development mechanism and related genes controlling polydactyly character of vertebrate are reviewed.
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| 关 键 词： | 脊椎动物 多趾 发生机理 候选基因 Key words vertebrate |
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