| 三例氨基糖甙类抗生素致聋患者的线粒体DNA测序分析 |
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| 引用本文： | 张丽珊,张志平,周晓雷,黄鹰,奚荣楠ZHANG Li-Shan,ZANG Zhi-Ping,ZHOU Xiao-Lei,HUANG Ying,XI Rong-Nan.三例氨基糖甙类抗生素致聋患者的线粒体DNA测序分析[J].遗传,1996,18(6):3-5. |
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| 作者姓名： | 张丽珊 张志平 周晓雷 黄鹰 奚荣楠ZHANG Li-Shan ZANG Zhi-Ping ZHOU Xiao-Lei HUANG Ying XI Rong-Nan |
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| 作者单位： | 南京铁道医学院生物学教研室, 南京 210009
Department of Biology,Nanjing Railway Medical Collge,Nanjing 210009 |
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| 摘 要： | 应用PCR扩增产物直接对3名氨基糖甙类抗生素致聋患者的线粒体DNA进行序
列分析, 结果表明,他们的线粒体DNA均存在第1555位核苷酸A-G的突变。因此认为该突
变是人体对氨基糖甙类抗生素致聋遗传易感性的分子基础,与氨基糖甙类抗生素共同作用造成耳聋。
Abstract:The mitochondria DNAs(mtDNAs)of three patients with AAID were analysed using the method of direct sequencing of their PCR products.The results showed that all their mtDNAs had an A-G mutation at nucleotides 1555.It is considered that this mutation is the molecular basis causing human susceptibility to Aminoglycoside Antibiotics toxicity which in cooperation with Aminoglycoside Antibiotics results in deafness.
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| 关 键 词： | 基因突变 Key words Aminoglycoside antibiotics induccd deafness(AAID) Mitochondria DNA (mtDNA) 氨基糖甙类抗生素致聋 线粒体DNA LIM结构 基因家族进化 TTG/RBTN T淋巴细胞肿瘤基因 |
Mitochondria DNA Sequence Analysis of 3 Cases with Aminoglycoside Antibiotics Induced Deafness |
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| Zhang Lishan, Zhang Zhiping, Zhou Xiaolei, Huang Ying ,Xi Rongnan.Mitochondria DNA Sequence Analysis of 3 Cases with Aminoglycoside Antibiotics Induced Deafness[J].Hereditas,1996,18(6):3-5. |
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| Authors: | Zhang Lishan Zhang Zhiping Zhou Xiaolei Huang Ying Xi Rongnan |
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| Abstract: | The mitochondria DNAs (mtDNAs) of thrce patients with AAID were analysed using the method of direct sequeneing of their PCR produets. The results showed that all their mtDNAs had an A-G mutation at nucleotides 1 555. It is considered that this mutation is the molecular basis causing human susceptibility to Aminoglycoside Antibiotics toxicity which in coopcration with Aminoglycoside Antibiotics results in deafness. |
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| Keywords: | Mitochondria DNA (mtDNA) Aminoglycoside antibiotics induced deafness(AAID) Gene mutation |
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