| 中国汉族人群原纤维蛋白-1基因(FBN1)第27内含子G/A多态性 |
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| 引用本文： | 陆振虞,陈仁彪,小林公子,李黎明,有波忠雄,滨口秀夫LU Zhen-Yu,CHEN Ren-Biao,K.Kobayashi,LI Li-Ming,T.Arinami,H.Hamaguchi.中国汉族人群原纤维蛋白-1基因(FBN1)第27内含子G/A多态性[J].遗传,1996,18(4):12-14. |
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| 作者姓名： | 陆振虞 陈仁彪 小林公子 李黎明 有波忠雄 滨口秀夫LU Zhen-Yu CHEN Ren-Biao K.Kobayashi LI Li-Ming T.Arinami H.Hamaguchi |
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| 作者单位： | 1.上海第二医科大学医学遗传学教研室, 上海 200025
2.日本国筑波大学医学遗传学教研室，上海市200025
1.Department of Medical Genetics,Shanghai Second Medical University,Shanhai 200025
2.Department of Medical Genetics,Institute of Basic Medical Science,University of Tsukuba,Tsukuba,305 Japan |
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| 摘 要： | 采用PCR-ASO方法, 对日本筑波大学101名中国汉族留学人员的DNA样品进行了原纤维蛋白-1基因(FBN1)第27内含子G/A多态性测定。结果发现,A等位基因频率为0.5396,G等位基因频率为0.4604。与Tynan等人报道的数据(A和G等位基因的频率分别为0.1675和0.8325)相比,有非常显著差异(P<0 .01),提示两样本间有不同的遗传背景。
Abstract:The G/A polymorphisms in intron 27 of fibrillin-1 gene in 101 Chinese Hans who were studying and working in University of Tsukuba,Japan were analyzed with PCR-ASO method.The frequencies of A and G alleles,were 0.5396 and 0.4604 respectively.In a population sample reported by Tynan the frequency of A allele was 0.1675 that of G allele was 0.8325.The distribution of G/A polymorphism was significantly different between the two population sample(P<0.01),suggesting different genetic backgrounds.
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| 关 键 词： | FBN1 gene ASO Key words PCR G/A多态性 FBN1基因 G-带 大麦 染色体 染色粒 |
Study on G/A Polymorphisms in Intron 27 of Fibrillin-1 Gene in Chinese Han Population |
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| Lu Zhenyu, Chen Renbiao.Study on G/A Polymorphisms in Intron 27 of Fibrillin-1 Gene in Chinese Han Population[J].Hereditas,1996,18(4):12-14. |
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| Authors: | Lu Zhenyu Chen Renbiao |
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| Abstract: | The G / A polymorphisms in intron 27 of fibrillin-1 gene in 101 Chinese Hans who were studying and working in University of Tsukuba, Japan were analyzed with PCR-ASO method. The frequencies of A and G alleles, were 0.5396 and 0.4604 respectively. In a population sample reported by Tynan the frequency of A allele was 0.1675 while that of G alle1e was 0. 8325. The distribution of G / A polymorphism was significantly different betwecn the two population sample (P<0. 01), suggesting different genetic backgrounds. |
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| Keywords: | FBN1 gene G/A polymorphism PCR ASO |
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