MTHFR基因多态性与动脉粥样硬化性脑梗塞的关系

采用PCR-RFLP技术，检测了62例动脉粥样硬化性脑梗塞患者和79名对照者的C677T突变的基因型。结果发现, MTHFR基因C677T 突变型等位基因(V)频率在实验组和对照组中，有显著性差异(χ2＝4.41，P<0.05)；三种基因型频率在两组人群中均无显著性差异。基因型频率的相对风险分析，AV基因型比AA基因型患脑梗塞风险高1.76倍；VV基因型比AA基因型患脑梗塞风险高3.25倍。结果表明, MTHFR基因C677T突变型等位基因与动脉粥样硬化性脑梗塞有一定的关联，突变基因型增加了动脉粥样硬化脑梗塞的发病风险。 Abstract:　In order to detect the relationship between MTHFRgene C677Tpolymorphism and arteriosclerotic cerebral infarction, this study examined the genotype of 62 patients with arteriosclerotic cerebral infarction and 79 control subjects by PCR-RFLP. The result showed that there was significance difference between patients and control subjects in V allele frequency of MTHFRgene C677Tmutation (χ2＝4.41，P<0.05) and there was no difference between patients and control subjects in genotype frequency of MTHFRgene C677Tmutation. The relative risk for arteriosclerotic cerebral infaction of heterozygote (AV/AA) was 1.76 and that of homozygote (VV/AA) was 3.25. The study confirmed an association between mutated allele of the MTHFRgene C677Tand arteriosclerotic cerebral infarction, mutated genotypes increased the risk of arteriosclerotic cerebral infarction.

Relation Between MTHFR Gene Polymorphism and Arteriosclerotic Cerebral Infarction