疟原虫入侵与红细胞内吞作用

用透射电镜观察红内期鼠疟原虫的入侵过程,发现红细胞在与裂殖子实际接触之前就发生很多种形状变化,主要有杯状和伪足两种类型。前者是红细胞与裂殖子相邻的一侧弯曲,形成与裂殖子表面相适应的凹陷;后者则是红细胞伸出突起或伪足逐渐接近裂殖子。附着之后,即逐渐扩展将其包围。在入侵中、后期,红细胞凹陷口周围呈波浪形突出,或者口部升高,凹陷壁逐渐变薄,有明显的前进趋势。这表明,红细胞在裂殖子诱导下,内吞活性增强了,有能力进行变形运动,包围裂殖子,从而以这种方式形成纳虫泡和使裂殖子进入其胞体内。

MALARIA PARASITE INVASION AND ERYTHROCYTE ENDOCYTOSIS

A TEM study on the behavior of .erythrocytes during, invasion by rodent malaria mero-zoites was carried out in vivo. It was found that various changes had taken place in the shape of the erythrocytes nearby the merozoites even before their contact. Basically, there were two types of deformation, i.e. cup-like and pseudopod-like. In the former case, the erythrocytes formed a concavity on the part adjacent to the merozoite to embrace the parasite. In the latter case, the erythrocytes produced protrusions or pseudopods to capture and surround the merozoites. At the middle and late stages of the invasion, the red cells obviously exhibited forward-advancing postures over the merozoite b raising of the orifice or tapering of the in-vagination wall as well as wavy projections. These morphollgical evidences suggested that the red cells were so strongly revived in their endocytic activity, due to the induction of the merozoites that they were able to conduct amoeboid movements to enclose the merbzoites. In this way, a parasitophorous vacuole might be formed and the interiorization of. the parasite realized.