Human hybrid immunoglobulin M containing immunoglobulin A |
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Authors: | Hiroshi Shinmoto Hiroki Murakami Shun-Ichi Dosako Koji Yamada Hirohisa Omura |
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Institution: | (1) Technical Research Institute, Snow Brand Milk Products Co., Ltd., 1-2 Minamidai 1-chome, 350 Kawagoe, Japan;(2) Institute of Food Science and Technology, Faculty of Agriculture, Kyushu University, 46-09, Higashi-ku, 812 Fukuoka, Japan |
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Abstract: | Summary Some hybridoma clones made by fusion of a human lymphoblastoid cell line, HO323 with human B lymphocytes, secreted not only
IgA but also IgM-like immunoglobulin molecules. The IgM-like immunoglobulin had a molecular size of 900 K which corresponded
to that of IgM. Immunochemical analyses revealed that the IgM-like immunoglobulin contained two monomeric IgA and three monomeric
IgM molecules. In the IgA moieties, half of original light chains were replaced withx chains derived from the IgM, and vice versa. |
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Keywords: | hybridoma IgM-like immunoglobulin bispecific antibodies |
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