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Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC |
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| Authors: | Oliver?Ebert Dorothee?Wilbert Peter?Buttgereit Carsten?Ziske Dimitri?Flieger |
| Institution: | 1.Medizinische Klinik und Poliklinik I,Rheinische Friedrich-Wilhelms-Universit?t,Bonn,Germany;2.Medizinische Klinik II,Klinikum Aschaffenburg,Germany;3.Department of Gene and Cell Medicine,Mount Sinai School of Medicine,New York,USA |
| Abstract: | BackgroundModulation of the immune system by genetically modified lymphoma cell vaccines is of potential therapeutic value in the treatment of B cell lymphoma. However, the anti-tumor effect of any single immunogene transfer has so far been limited. Combination treatment of recombinant IL-2 and IL-12 has been reported to be synergistic for inducing anti-tumor responses in solid tumors but the potential of IL-2/IL-12 gene modified B cell lymphoma cells has not been explored yet. |
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