Estrogen stimulation of ovarian surface epithelial cell proliferation |
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Authors: | Wenlong Bai Beatriz Oliveros-Saunders Qiang Wang Mildred E Acevedo-Duncan Santo V Nicosia |
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Institution: | (1) H. Lee Moffitt Cancer Center and Research Institute, 33612 Tampa, Florida;(2) Department of Pathology, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC Box 11, 33612-4799 Tampa, Florida |
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Abstract: | Summary Ovarian cancer is the leading cause of gynecological cancer mortality, and 85–90% of this malignancy originates from the ovarian
surface epithelium (OSE). The etiology of ovarian epithelial cancer is unknown but a role for estrogens has been suspected.
However, the effect of estrogens on OSE cell proliferation remains to be determined. Using the rabbit model, our studies have
demonstrated that 17β-estradiol stimulates OSE cell proliferation and the formation of a papillary ovarian surface morphology
similar to that seen in human ovarian serous neoplasms of low malignant potential. Immunohistochemical staining of ovarian
tissue sections with an antibody to the estrogen receptor α demonstrates its expression in both OSE cells and stromal interstitial
cells. In primary ovarian cell cultures, the proliferative response of the epithelial cells to 17β-estradiol depends on the
expression of the estrogen receptor α in the epithelial cells. However, when the epithelial cells are grown together with
ovarian stromal cells, their proliferative response to this hormone is greatly enhanced, suggesting the involvement of stromal-epithelial
interactions. These studies suggest a role for estrogens and the estrogen receptor α in OSE growth. |
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Keywords: | ovarian cancer estrogen receptor ovarian surface epithelium proliferation stromal-epithelial interactions |
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