Effect of testosterone on adrenal corticosteroidogenesis in lithium treated male rats |
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| Authors: | D Ghosh N M Biswas A Chaudhuri P K Ghosh |
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| Institution: | Department of Physiology, University College of Science, Calcutta, India. |
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| Abstract: | Lithium chloride at a dose of 200 micrograms/100 g body weight/day given for 21 days caused a significant increase in adrenal weight, adrenal 5-ene-3 beta-hydroxysteroid dehydrogenase (5-ene-3 beta-HSD) activity along with elevation in serum level of corticosterone on the 22nd day in the rat. Administration of testosterone for the last 14 days to lithium treated rats caused a significant decrease in adrenal weight, adrenal 5-ene-3 beta-HSD activity and serum level of corticosterone in comparison to lithium treated animals. |
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