Three new compounds isolated from the bulbs of Fritillaria pallidiflora Schrenk and their anti-inflammatory activity |
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| Institution: | 1. College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China;2. Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China;3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China;1. Gilson Purification, 22 rue Bourseul, ZI du Poteau, 56890, Saint Ave, France;2. AsterBioChem Research Team, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café s/n, Ribeirão Preto, SP, 14040-903, Brazil;1. College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650500, China;2. Department of Oncology, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, 650599, China;1. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China;2. Analytical & Measuring Center of School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China;1. Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;2. Centro de Investigación en Biología Celular y Molecular, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;3. Centro de Electroquímica y Energía Química, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;4. Escuela de Química, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;1. Pharmacy Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, China;2. College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430070, China;3. Department of Pharmaceutical Science, Medical College, Hunan Normal University, Changsha 410013, China;1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China;2. Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou, 510006, China |
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| Abstract: | Three new compounds, 17β-cevanin-6-oxo-5α,20β-diol yibeinine (1), 2-(tetrahydro-5-(2-hydroxyphenyl)-2H-pyran-3-yl) phenol (2), 1,3-O-diferuloyl-2-methoxypropane diol (3), as well as four known compounds (4–7), have been isolated from the ethanol extract of dried bulbs of Fritillaria pallidiflora Schrenk. All structures were determined based on their spectroscopic data (1D and 2D NMR (including 1H NMR, 13C NMR, 1H-1H COSY, HMBC, HSQC, HSQC-TOCSY, and NOESY experiments), and MS). Biological evaluation showed that compounds 1–4 inhibited the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells with IC50 values of 18.0, 38.7, 29.5, and 47.1 μM, respectively. These results indicated that compound 1 has potential anti-inflammatory activity. |
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| Keywords: | Alkaloids Isosteroidal alkaloids Phenylpropionic acid derivatives Anti-inflammatory activity |
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