Two new steroidal saponins from Dioscorea panthaica |
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| Authors: | Xiao Liang Zhao Wen Guang Jing Shu Ying Han Guang Li Sun Yu Mei Liu Qi Wei Zhang Xiao Jun Ma Zhi Min Wang An Liu |
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| Institution: | aInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China;bInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 6 Nanxiaojie, Dongzhimenneiave, Beijing 100700, China;cNorth China Coal Medical University, Tangshan 063000, China |
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| Abstract: | Two new furostanol saponins, 3-O-α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl]-26-O-β-d-glucopyranosyl-25(R)-furosta-5,22(23)-dien-3β,20α,26-triol (1), 3-O-β-d-glucopyranosyl-(1→3)-O-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl]-26-O-β-d-glucopyranosyl-20(R)-methoxyl-25(R)-furosta-5,22(23)-dien-3β,26-diol (2) were isolated from the Dioscorea panthaica along with five known steroidal saponins (3–7). The structures of the new saponins were determined by detailed analysis of spectral data (including 2D NMR spectroscopy). The inhibitory activities of the saponins against α-glucosidase were investigated, gracillin (4) and 3-O-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl]-26-O-β-d-glucopyranosyl-25(R)-furosta-5,20(22)-dien-3β,26-diol (5) were found to exhibit potent activities with IC50 values of 0.11 ± 0.04 mM and 0.09 ± 0.01 mM. |
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| Keywords: | Steroidal saponin Dioscorea panthaica α-Glucosidase inhibitory activity |
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