Geranylated tetraoxygenated xanthones from the pericarp of Garcinia pedunculata |
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| Institution: | 1. Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, VNUHCM—University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam;2. Food Industry Research Institute, Branch in Ho Chi Minh City, 58 Nguyen Binh Khiem, Ho Chi Minh City, Viet Nam;1. Theoretical and Physical Chemistry Division, Dong Thap University, 783-Pham Huu Lau, Ward 6, Cao Lanh City, Dong Thap, Viet Nam;2. Department of Chemistry, University of Science, Vietnam National University – Ho Chi Minh City, 227 Nguyen Van Cu, District 5, Ho Chi Minh City, Viet Nam;1. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;2. Jiangzhong Pharmaceutical Group Company Limited, Nanchang 330096, China;3. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;4. Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama 930-0194, Japan;1. Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, P. R. China;2. Reyoung Pharmaceutical Co., Ltd, No. 44 Cultural West Road, Jinan 250012, P. R. China;1. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;2. School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;1. Ukrainian Institute of Agricultural Radiology of National University of Life and Environmental Sciences of Ukraine, Mashinobudivnykiv str.7, Chabany, Kyiv region, 08162 Ukraine;2. Institute of Environmental Radioactivity of Fukushima University, 1 Kanayagawa, Fukushima City, Fukushima Prefecture, 960-1296, Japan |
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| Abstract: | Three new xanthones, pedunxanthones D-F (1–3), along with ten known compounds, were isolated from a chloroform extract of the pericarp of Garcinia pedunculata. Their structures were determined using spectroscopic techniques. Cytotoxicity against HeLa and NCI-H460 cells of the isolated compounds using an SRB assay was evaluated with pedunxanthone D (1) as the most active compound (IC50 24.9 ± 0.4 and 26.1 ± 1.5 μg/ml, respectively). |
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| Keywords: | Guttiferae Xanthones Pedunxanthones D-F Structure determination Cytotoxicity |
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