Two new phenolic compounds from the white flower of Impatiens balsamina |
| |
| Institution: | 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea;2. Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea;3. College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea;4. Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea;5. Dong-A ST Research Institute, Kiheung, Yongin 17073, Republic of Korea;1. Department of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland;2. Department of Medicinal Chemistry, Faculty of Pharmacy, Medical College, Jagiellonian University, ul. Medyczna 9, 30-688 Kraków, Poland;3. Departament of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland;1. UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Oman;2. Department of Chemistry, Federal Urdu University of Arts, Science and Technolgy, Karachi, Pakistan;3. Martin-Luther Universität Halle-Wittenberg, Organische Chemie, Kurt-Mothes-Str. 2, D-06120 Halle, Germany;4. Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan;5. Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman;6. Department of Chemistry and Polymer Science, University of Stellenbosch, P/Bag X1, Matieland 7602, South Africa;7. DARIS Centre for Scientific Research and Technology Development, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Oman;1. Department of Biotechnology, College of Biomedical & Health Science, Konkuk University, Chungju, Republic of Korea;2. Department of Food Science and Engineering, Seowon University, Cheongju, Republic of Korea;3. Division of Biological Science and Technology, Institute of Biomaterials, Yonsei University, Wonju, Republic of Korea;1. Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan;2. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan;3. School of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;4. Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan;5. Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan;6. School of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan;7. Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan;8. Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan;9. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;10. Center of Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan;1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China;2. Department of Phytochemistry, Second Military Medical University, Shanghai 200433, PR China |
| |
| Abstract: | During the course of our continuing search for biologically active compounds from Korean medicinal sources, we investigated the white flower of Impatiens balsamina. From the MeOH extract, two new phenolic compounds (1–2) containing a nitrile group and eleven known phenolic compounds (3–13) were isolated. The chemical structures of new compounds (1–2) were determined through NMR, HRMS, and CD data. We tested the isolated compounds (1–13) for their cytotoxic activities by determining their inhibitory effects on human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay. We also investigated their neuroprotective activity by determining their effects on nerve growth factor (NGF) secretion in C6 cells, and anti-neuroinflammatory activity by measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV-2 cells. |
| |
| Keywords: | Balsamineaceae Phenolic compounds Cytotoxicity Neuroprotection Anti-neuroinflammation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
