Bafouoside C,a new triterpenoid saponin from the roots of Cussonia bancoensis Aubrev. & Pellegr. |
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| Institution: | 1. Laboratory of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Box 183, Dschang, Cameroon;2. School of Science and Technology, Chemistry Division, University of Camerino, Via S. Agostino 1, I-62032 Camerino, Italy;3. Laboratoire de Pharmacognosie, UFR des Sciences de Santé (Pharmacie), EA 4267 (FDE/UFC), Université de Bourgogne, 7, Boulevard Jeanne d’Arc, BP 87900, 21079 Dijon Cedex, France;4. School of Pharmacy, Physiology Division, University of Camerino, Via Gentile III da Varano, I-62032 Camerino, Italy;1. State Key Laboratory of Organic–Inorganic Composites, Beijing University of Chemical Technology, 100029 Beijing, PR China;2. Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, KP, Pakistan;1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, PR China;2. Yunnan Academy of Tobacco Science, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650106, PR China;1. Laboratoire de Biogéochimie Moléculaire, Institut de Chimie de Strasbourg, UMR 7177, Université de Strasbourg, CNRS, ECPM, 25 rue Becquerel, 67200 Strasbourg, France;2. Laboratoire Image, Ville, Environnement, UMR 7362, Faculté de Géographie et d’Aménagement, Université de Strasbourg, CNRS, 3 rue de l’Argonne, 67083 Strasbourg Cedex, France;3. INRAP Grand Est Sud, 10 rue d’Altkirch, 67100 Strasbourg, France;4. Centre de Géochimie de la Surface, UMR 7517, Université de Strasbourg, CNRS, EOST, 1 rue Blessig, 67084 Strasbourg, France;1. Department of Organic Chemistry, Faculty of Science, The University of Yaoundé I, P.O. Box 812, Yaounde, Cameroon;2. Institute of Medical Research and Medicinal Plant Studies, Ministry of Scientific Research and Innovation, P.O. Box 6163, Yaoundé, Cameroon;3. Department of Chemistry, University of Botswana, Private Bag 00704, Gaborone, Botswana;4. Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland;1. Faculty of Pharmacy, Umm Al-Qura University, Makka, Saudi Arabia;2. Faculty of Pharmacy (Girls), Al-Azhar University, Nasr-City, Cairo, Egypt;3. Faculty of Pharmacy, Egyptian-Russian University, Cairo, Egypt;4. National Organization for Drug Control and Research, Dokki, P.O. 29, Cairo, Egypt |
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| Abstract: | A new triterpenoid saponin named bafouoside C 3-O-β-d-glucopyranosyl-(1 → 4)-β-d-galactopyranosyl-(1 → 2)]-β-d-glucuronopyranosyloleanolic acid 28-O-β-d-glucopyranosyl ester; (1), together with five known compounds 3-O-β-d-galactopyranosyl-(1 → 2)-β-d-glucuronopyranosyloleanolic acid (2), 23-hydroxyursolic acid (3), 28-O-α-l-rhamnopyranosyl-(1 → 4)-O-β-d-glucopyranosyl-(1 → 6)-O-β-d-glucopyranosyl-23-hydroxyursolic acid (4), 3-O-β-d-glucopyranosyl-23-hydroxyursolic acid (5), and 3-O-α-l-arabinopyranosyl-23-hydroxyursolic acid (6), were isolated from the roots of Cussonia bancoensis Aubrev. & Pellegr. Their structures were established on the basis of 1D- and 2D NMR data, mass spectrometry and chemical methods. The NMR data of the known compounds, as far as we know, are herein reported for the first time in CD3OD. Compound 3 exhibited a weak cytotoxic activity against MDA-MB 231 human breast adenocarcinoma, A375 human malignant melanoma, and HCT116 human colon carcinoma cell lines. |
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| Keywords: | Araliaceae Saponins Oleanane triterpenoid |
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