Antiproliferative constituents from Aphananthe aspera leaves |
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| Institution: | 1. State Forestry Administration Key Open Laboratory, International Centre for Bamboo and Rattan, Beijing 100102, China;2. School of Plant Protection, Anhui Agricultural University, Hefei 230036, China;1. Marine Drugs Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China;2. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China;1. Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Avenue, Nanchang 330004, Jiangxi, PR China;2. Technology Center, Jiangzhong Group, 618 Huoju Road, Nanchang 330096, Jiangxi, PR China;3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China;1. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan;2. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan;3. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan;4. Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan;5. Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan;6. Department of Cosmeceutics, China Medical University Hospital, China Medical University, Taichung 404, Taiwan;7. Department of Exercise Health Science, National Taiwan University of Physical Eucation and Sport, Taichung 404, Taiwan;8. Department of Biotechnology, Asia University, Taichung 413, Taiwan |
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| Abstract: | Extensive screening for the antiproliferative activity of different compounds found in trees was performed by extracting the leaves of Aphananthe aspera (Thunb.) Planch and then using chromatographic separation to afford 2 new compounds, (2S,4R)-2-carboxy-4-(E)-p-caffeoyl-1-methyl-hydroxyproline (1) and 5-O-caffeoyl quinic acid-(7′R,8′S,7′′E)-3′,4′,3′′-dihydroxy-4′′,7′-epoxy-8′,5′′-neolign-7′-ene-9- carboxyl (2). In addition, 6 known compounds were discovered from the leaves of this plant. The structural determination of all compounds, including their absolute configurations, was established by UV, IR, HRESIMS, 1D and 2D NMR, and CD spectroscopy. The novel compound 1 showed strong antiproliferative activity against human breast adenocarcinoma cells MCF-7 and MDA-MB-231. |
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| Keywords: | Anti-proliferative activity |
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