Depsidones from Talaromyces stipitatus SK-4, an endophytic fungus of the mangrove plant Acanthus ilicifolius |
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| Institution: | 1. School of Chemistry, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China;2. School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China;3. College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China;1. Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 CNRS/MNHN, Muséum National d’Histoire Naturelle, 57 rue Cuvier (CP54), 75231 Paris Cedex 05, France;2. Laboratoire de Pharmacognosie, UMR 8638 CNRS, Faculté des Sciences Pharmaceutiques et Biologiques, Paris Descartes University, Sorbonne Paris Cité, 4 Avenue de l’Observatoire, 75006 Paris, France;3. Cancer Biology and Therapeutics, Centre de Recherche Saint-Antoine, Institut Universitaire de Cancérologie, Université Pierre et Marie Curie, Sorbonne Universités et Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 938, Hôpital Sant-Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France;1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;2. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China;3. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China;4. Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;5. National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand;1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning, China;2. New Drug Research and Development Center, North China Pharmaceutical Group Corporation and National Microbial Medicine Engineering and Research Center, Shijiazhuang 050015, China;1. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, PR China;2. University of the Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, PR China;1. Faculty of Science and Industrial Technology, Prince of Songkla University, Surat Thani Campus, Surat Thani 84100, Thailand;2. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;3. Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;4. National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand;1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China;2. Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand |
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| Abstract: | An endophytic fungus (Talaromyces stipitatus SK-4) was isolated from the leaves of a mangrove plant Acanthus ilicifolius. Its crude extract exhibited significant antibacterial activity and was purified to afford two new depsidones, talaromyones A and B (1 and 2), along with five known depsidone analogs (3–7). Their structures, including absolute configuration, were elucidated through extensive spectroscopic data analysis and modified Mosher's method. Compound 2 showed antibacterial activity against Bacillus subtilis with an MIC value of 12.5 μg/mL. In the inhibitory assay against α-glucosidase, compounds 2, 4 and 5 displayed moderate activities with IC50 values ranging from 48.4 to 99.8 μM. |
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| Keywords: | Endophytic fungus Depsidones Antibacterial activity |
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