Cytotoxic,antimicrobial activities,AChE and BChE inhibitory effects of compounds from Tanacetum chiliophyllum (Fisch. & Mey.) Schultz Bip. var. oligocephalum (D.C.) Sosn. and T. chiliophyllum (Fisch. & Mey.) Schultz Bip. var. monocephalum Grierson |
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| Institution: | 1. Altinbas University, Faculty of Pharmacy, Department of Analytical Chemistry, 34147, Istanbul, Turkey;2. Altinbas University, Faculty of Pharmacy, Department of Biochemistry, 34147, Istanbul, Turkey;3. Ege University, Faculty of Engineering, Department of Bioengineering, 35100, Bornova, Izmir, Turkey;4. Ege University, Faculty of Science, Department of Biology, 35100, Bornova, Izmir, Turkey;5. Yildiz Technical University, Faculty of Science & Letters, Department of Molecular Biology and Genetics, 34210, Istanbul, Turkey;1. Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt;3. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;4. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt;5. National Center for Natural Products Research, Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, MS 38677, USA;1. Department of Pharmacognosy, Faculty of Pharmacy, Medical University-Sofia, Bulgaria;2. Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, Bulgaria;3. Department of Biology, Science Faculty, Selcuk University, Konya, Turkey;4. Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam;5. Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius;1. UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Oman;2. Department of Chemistry, Federal Urdu University of Arts, Science and Technolgy, Karachi, Pakistan;3. Martin-Luther Universität Halle-Wittenberg, Organische Chemie, Kurt-Mothes-Str. 2, D-06120 Halle, Germany;4. Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan;5. Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman;6. Department of Chemistry and Polymer Science, University of Stellenbosch, P/Bag X1, Matieland 7602, South Africa;7. DARIS Centre for Scientific Research and Technology Development, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Oman;1. Department of Pharmacognosy, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, 12311, Cairo, Egypt;2. Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, African Union Organization Street, 11566, Cairo, Egypt;1. Mayo Clinic, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Minnesota, USA;2. Mayo Clinic College of Medicine, Department of Experimental Pathology, Minnesota, USA;3. Progen Pharmaceuticals Ltd, Brisbane, Queensland, Australia;4. Henry Ford Health System, Neurology Research, Detroit, MI, USA;5. University of Minnesota, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Minnesota, USA;6. Department of Cancer Biology, University of Kansas Cancer Center, Kansas City, Kansas, USA;7. Mayo Clinic College of Medicine, Department of Medical Oncology, Minnesota, USA;8. Department of Medical Oncology, Sir Charles Gairdner Hospital & University of Western Australia, Australia;1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea;2. Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea;3. College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea;4. Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea;5. Dong-A ST Research Institute, Kiheung, Yongin 17073, Republic of Korea |
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| Abstract: | Tanacetum L. species traditionally used for insecticidal purposes as well as in folk medicine for their antitumor, antimicrobial, antifungal activities. In our previous study a novel sesquiterpene lactone and triterpene lactone together with 12 known flavonoids, coumarin and a triterpene were isolated from T. chiliophyllum var. oligocephalum and T. chiliophyllum var. monocephalum extracts which have insecticidal and antimicrobial activity. In this study, cytotoxic, antimicrobial activities and acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory effects of pure compounds isolated from these plants were investigated. The tested compounds showed AChE and BChE inhibition which ranged between 7.20–80.37% and 9.19%–76.99% respectively. The highest AChE and BChE inhibition was observed for ulubelenolide which afforded 80.37% and 76.99% inhibition respectively. The cytotoxic effect of the compounds ranged between 22.34–49.77 μg/mL IC50 values. Highest cytotoxic activity was observed against MCF-7 and HEK 293 cell line by 5–hydroxy-3′,4′,7-trimethoxy flavone and 5-hydroxy-3′,4′,6,7-tetramethoxyflavone that produced 25.80 ± 0.17 and 22.34 ± 0.70 IC50 values respectively. Compounds eupatilin, cirsilineol, 5–hydroxy-3′,4′,7-trimethoxy flavone and ulubelenolide showed significant antimicrobial effect on C. albicans with 7.8 μg/mL MIC. The new compound ulubelenolide afforded high AChE and BChE inhibition as well as high antifungal activity. In our opinion activity of this substance should be evaluated further against other fungal species. |
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| Keywords: | AChE BChE Cytotoxic activity Antimicrobial activity Ulubelenolide |
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