Bioactive compounds from Rumex plants |
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| Authors: | Heng-Xing Liang Huan-Qin Dai Hai-An Fu Xiao-Ping Dong Abiodun Humphrey Adebayo Li-Xin Zhang Yong-Xian Cheng |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People''s Republic of China;2. Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People''s Republic of China;3. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, People''s Republic of China;4. Department of Pharmacology, Emory University School of Medicine and Emory Chemical Biology Discovery Center, Atlanta, GA 30322, USA |
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| Abstract: | Two new naphthalene acylglucosides, rumexneposides A (1) and B (2), together with 12 known compounds (3-14), were isolated from the roots of Rumex nepalensis. Their structures were established by chemical and spectroscopic methods. The biological activities of compounds 1-14 as well as an additional 11 compounds previously isolated from R. nepalensis and Rumex hastatus (15–25) were evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of human cancer cell lines. The results showed that compound 15 was the most active against M. tuberculosis with an MIC value of 2.85 μM similar to that of isoniazid. Compound 5 could inhibit pAba synthetic pathway with an MIC value of 12.6 μM, comparable to that of positive control abyssomicin C, representing a new example of the rare pAba pathway inhibitors. |
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