Microbial transformation of bavachin by Absidia coerulea |
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| Institution: | 1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, PR China;2. PET-CT Center, The Second Xiangya Hospital of Central South University, Changsha 410011, PR China;3. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China;4. Department of Anesthesiology, The Second Xiangya Hospital of Central South University, Changsha 410011, PR China;1. Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China;2. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, PR China;3. Pharmaceutical Engineering Department, School of Biological Science and Technology, University of Jinan, Shandong 250022, PR China;1. Center of Research and Development on Life Sciences and Environment Sciences, Harbin University of Commerce, Harbin 150076, China;2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China;3. Institute of Medicine Plantationof Chongqing, Chongqing 408435, China;4. College of chemistry and materials science, Guangxi Teachers Education University, Manning 530001, China;1. Computer Science Department, University of Neuchatel, Switzerland;2. Institute of Networked and Embedded Systems, Alpen-Adria Universität Klagenfurt, Austria;3. E-learning Department, MTA SZTAKI, Hungary;4. Institute of Information Technology, Alpen-Adria Universität Klagenfurt, Austria;1. Unidade de Biotecnologia, Universidade de Ribeirão Preto, Av. Costábile Romano, 2201, 14096-900, Brazil;2. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café s/n, 14040-903, Brazil;1. Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China;2. Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China;3. Chemistry and Chemical Engineering College, Chongqing University, Chongqing 400030, PR China;4. University of the Chinese Academy of Sciences, Beijing 100049, PR China |
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| Abstract: | Microbial transformation of bavachin (1), one of the major bioactive components of Psoralea corylifolia L., was performed by using Absidia coerulea. Three oxidized metabolites were obtained in the biotransformation of 1, and their structures were elucidated as bavachinone A (2), (2S)-4′-hydroxy-6,7-(R)-2-(1-hydroxy-1-methylethyl)-2,3-dihydrofurano]flavanone (3), and (2S)-4′,7-dihydroxy-6-(2,3-dihydroxy-3-methylbutyl)flavanone (4) based on the spectroscopic analyses. Among them, metabolites 3 and 4 were new compounds. The biotransformation study suggested that 1 was fully oxidized to its metabolites within 5 days. Thus, biotransformation by A. coerulea can be used as a promising method for oxidation of bavachin. |
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| Keywords: | Microbial transformation Bavachin Oxidation reaction |
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