Withaphysalin-type withanolides from Physalis minima |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. Department of Dermatology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China;4. Research Institute of Resource Insects, Chinese Academy of Forestry, Kunming 650224, China |
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| Abstract: | Nine new withaphysalin-type withanolides (1–9), named physaminimins (G-O) were isolated from the whole plants of Physalis minima Linn. The structures of these compounds were elucidated based on spectroscopic methods (1D NMR, HSQC, HMBC, ROESY) and HRESIMS. Physaminimins G, H, and K showed inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in a macrophage (RAW264.7) cells with IC50 values of 17.41 ± 1.04, 36.33 ± 1.95 and 21.48 ± 1.67 μM, respectively. |
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| Keywords: | Withanolides Nitric oxide Solanaceae |
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