Multiplicity of Quorum Quenching Enzymes: A Potential Mechanism to Limit Quorum Sensing Bacterial Population |
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| Authors: | Shikha Koul Vipin Chandra Kalia |
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| Institution: | 1.Microbial Biotechnology and Genomics,CSIR - Institute of Genomics and Integrative Biology (IGIB),Delhi,India;2.Academy of Scientific and Innovative Research (AcSIR),New Delhi,India |
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| Abstract: | Bacteria express certain of their characteristics especially, pathogenicity factors at high cell densities. The process is termed as quorum sensing (QS). QS operates via signal molecules such as acylhomoserine lactones (AHLs). Other bacteria inhibit QS through the inactivation of AHL signals by producing enzymes like AHL-lactonases and -acylases. Comparative genomic analysis has revealed the multiplicity of genes for AHL lactonases (up to 12 copies per genome) among Bacillus spp. and that of AHL-acylases (up to 5 copies per genome) among Pseudomonas spp. This genetic evolution can be envisaged to enable host to withstand the attacks from bacterial population, which regulates its functioning through QS. |
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