Bioactive compounds from marine actinomycetes |
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Authors: | Renu Solanki Monisha Khanna Rup Lal |
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Institution: | (1) Acharya Narendra Dev College, University of Delhi, Govindpuri, Kalkaji, New Delhi, 110 019, India;(2) Molecular Biology Lab, Department of Zoology, University of Delhi, Delhi, 110 007, India |
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Abstract: | Actinomycetes are one of the most efficient groups of secondary metabolite producers and are very important from an industrial
point of view. Among its various genera, Streptomyces, Saccharopolyspora, Amycolatopsis, Micromonospora and Actinoplanes are the major producers of commercially important biomolecules. Several species have been isolated and screened from the
soil in the past decades. Consequently the chance of isolating a novel actinomycete strain from a terrestrial habitat, which
would produce new biologically active metabolites, has reduced. The most relevant reason for discovering novel secondary metabolites
is to circumvent the problem of resistant pathogens, which are no longer susceptible to the currently used drugs. Existence
of actinomycetes has been reported in the hitherto untapped marine ecosystem. Marine actinomycetes are efficient producers
of new secondary metabolites that show a range of biological activities including antibacterial, antifungal, anticancer, insecticidal
and enzyme inhibition. Bioactive compounds from marine actinomycetes possess distinct chemical structures that may form the
basis for synthesis of new drugs that could be used to combat resistant pathogens. |
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Keywords: | Marine actinomycetes Bioactive compounds |
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