| Following a TRAIL： Update on a ligand and its five receptors |
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| 作者姓名： | Kimberley FC Screaton GR |
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| 作者单位： | [1]WeatherallInstituteofMolecularMedicine,HumanImmunologyUnit,JohnRadcliffeHospital,OxfordOX39DS,UK [2]DepartmentofMedicine,HammersmithHospital,ImperialCollege,DuCaneRoad,LondonW12ONNUK |
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| 摘 要： | Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family ligand, sparked a torrent of research, following an initial observation that it could kill tumour cells, but spare normal cells. Almost a decade after its discovery, and with five known receptors, the true physiological role of TRAIL is still debated and its anti-tumorigenic properties limited by potential toxicity. This review takes a comprehensive look at the story of this enigmatic ligand,addressing its remaining potential as a therapeutic and providing an overview of the TRAIL receptors themselves.
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| 关 键 词： | 肿瘤坏死因子细胞凋亡诱导配位子 受体 癌症 细胞凋亡 治疗 |
Following a TRAIL: update on a ligand and its five receptors |
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| Kimberley FC,Screaton GR.Following a TRAIL: update on a ligand and its five receptors[J].Cell Research,2004,14(5):359-372. |
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| Authors: | Kimberley Fiona C Screaton Gavin R |
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| Institution: | Department of Medicine, Hammersmith Hospital, Imperial College, Du Cane Road, London, UK. |
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| Abstract: | Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family ligand, sparked a torrent of research, following an initial observation that it could kill tumour cells, but spare normal cells. Almost a decade after its discovery, and with five known receptors, the true physiological role of TRAIL is still debated and its anti-tumorigenic properties limited by potential toxicity. This review takes a comprehensive look at the story of this enigmatic ligand, addressing its remaining potential as a therapeutic and providing an overview of the TRAIL receptors themselves. |
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| Keywords: | TRAIL apoptosis cancer |
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