| Role of JNK activation in apoptosis： A double-edged sword |
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| 作者姓名： | Liu J Lin A |
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| 作者单位： | BenMayInstituteforCancerResearch,TheUniversityofChicago,5841S.MarylandAvenue,MC6027,Chicago,IL60637,USA |
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| 摘 要： | JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF-α induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies reveal that JNK can suppress apoptosis in IL-3-dependent hematopoietic cells via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Thus, JNK has pro- or antiapoptotic functions, depending on cell type, nature of the death stimulus, duration of its activation and the activity of other signaling pathways.
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| 关 键 词： | JNK激酶 活化作用 细胞凋亡 NF-KB TNF-β IL-3 细胞信号转导途径 |
Role of JNK activation in apoptosis: a double-edged sword |
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| Liu J,Lin A.Role of JNK activation in apoptosis: a double-edged sword[J].Cell Research,2005,15(1):36-42. |
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| Authors: | Liu Jing Lin Anning |
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| Institution: | Ben May Institute for Cancer Research, The University of Chicago, 5841 S. Maryland Avenue, MC 6027, Chicago, IL 60637, USA. |
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| Abstract: | JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-kB activation, prolonged JNK activation contributes to TNF-a induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies reveal that JNK can suppress apoptosis in IL-3-dependent hematopoietic cells via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Thus, JNK has pro- or antiapoptotic functions, depending on cell type, nature of the death stimulus, duration of its activation and the activity of other signaling pathways. |
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