| Developmental changes in functional expression andβ-adrenergic regulation of I_f in the heart of mouse embryo |
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| 作者姓名： | GUI Li SONG MING TANG CHANG JIN LIU HONG YAN LUO HUA MIN LIANG XIN Wu HU JIAOYA XI LIN LIN GAO BERND FLEISCHMANN JURGEN HESCHELER |
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| 作者单位： | GUI Li SONG，MING TANG，CHANG JIN LIU，HONG YAN LUO，HUA MIN LIANG，XIN Wu HU，JIAOYA XI，LIN LIN GAO，BERND FLEISCHMANN，JURGEN HESCHELER Department of Physiology，Tongji Medical College of Huazhong University of Science and Technology，Wuhan 430030，China Institute of Neurophysiology，University of Cologne，D-50931 Cologne，Germany |
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| 摘 要： | The hyperpolarization-activated current (If) plays an important role in determining the spontaneous rate of cardiac pacemaker cells. The automatic rhythmicity also exists in working cells of embryonic heart, therefore we studied developmental changes in functional expression and β-adrenergic regulation of Iy in embryonic mouse heart. The expression of If is high in early developmental stage (EDS) (10.5 d after coitus) ventricular myocytes, low in intermediate developmental stage (IDS) (13.5 d) atrial or ventricular myocytes and even lower in late developmental stage (LDS) (16.5 d) atrial or ventricular myocytes, indicating that these cells of the EDS embryonic heart have some properties of pacemaker cells.β-adrenergic agonist isoproterenol (ISO) stimulates If in LDS but not in EDS cardiomyocytes, indicating that the β-adrenergic regulation of If is not mature in EDS embryonic heart. But forskolin (a direct activator of adenylate cyclase) and 8-Br-cAMP (a membrane-permeable analogue of cAMP) increase t
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| 关 键 词： | embryonic cardiomyocyte development If β-adrenergic. |
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