| MAPK signal pathways in the regulation of cell proliferation in mammalian cells |
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| 作者姓名： | Zhang W Liu HT |
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| 作者单位： | WEI ZHANG，Hui Tu LIU The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education，College of Life Sciences，Beijing Normal University，Beijing 100875，China |
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| 基金项目： | supported by the Major State
Basic Research Project (Grant No. G1999053901). |
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| 摘 要： | INTRODUCTIONMitogen-activated protein kinaJse (MAPK) cas-cades have been shown to play a key role in trans-duction extracellular signals to cellular responses. Inmammalian cells, three MAPK families have beenclearly characterized: namely classical MAPK (alsoknown as ERK), C-Jun N-terminal kinse/ stress-activated protein kinase (JNK/SAPK) and p38 ki-nase. MAP kinases lie within protein kinase cas-cades. Each cascade consists of no fewer than threeenzymes that are activated in se…
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| 关 键 词： | 促细胞分裂剂活化蛋白激酶 细胞增殖 哺乳动物 MAPK |
MAPK signal pathways in the regulation of cell proliferation in mammalian cells |
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| Zhang W,Liu HT.MAPK signal pathways in the regulation of cell proliferation in mammalian cells[J].Cell Research,2002,12(1):9-18. |
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| Authors: | Zhang Wei Liu Hui Tu |
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| Institution: | The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, China. |
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| Abstract: | MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPI(families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above effects are fulfilled by regulation of cell cycle engine and other cell proliferation related proteins. In this paper we discussed their functions and cooperation with other signal pathways in regulation of cell proliferation. |
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| Keywords: | MAPK ER K JNK/SPAK p38 cell proliferation cross-talk |
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