| Transgenic mice overexpressing γ—aminobutyric acid transporter subtype I develop obesity |
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| 作者姓名： | Ma YH Hu JH Zhou XG Zeng RW Mei ZT Fei J Guo LH |
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| 作者单位： | InstituteofBiochemistryandCellBiology,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyofScience |
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| 摘 要： | Transgenic mice ubiquitously overexpressing murine γ-aminobutyric acid transporter subtype I were created.Unexpectedly,these mice markedly exhibited heritable obesity,which features significantly increased body weight and fat deposition.Behavioral examination revealed that transgenic mice have slightly reduced spontaneous locomotive capacity and altered feeding pattern.This preliminary finding indicates that the inappropriate level of γ-aminobutyric acid transporters may be directly or indirectly involved in the pathogenic mechanism underlying certain types of obesity.
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| 关 键 词： | γ－氨基丁酸 GABA转运蛋白亚型I 转基因鼠 肥胖症 过表达 GAT1 神经递质 |
Transgenic mice overexpressing gamma-aminobutyric acid transporter subtype I develop obesity |
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| Ma YH,Hu JH,Zhou XG,Zeng RW,Mei ZT,Fei J,Guo LH.Transgenic mice overexpressing gamma-aminobutyric acid transporter subtype I develop obesity[J].Cell Research,2000,10(4):303-310. |
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| Authors: | Ma Y H Hu J H Zhou X G Zeng R W Mei Z T Fei J Guo L H |
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| Institution: | Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai. |
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| Abstract: | Transgenic mice ubiquitously overexpressing murine gamma-aminobutyric acid transporter subtype I were created. Unexpectedly, these mice markedly exhibited heritable obesity, which features significantly increased body weight and fat deposition. Behavioral examination revealed that transgenic mice have slightly reduced spontaneous locomotive capacity and altered feeding pattern. This preliminary finding indicates that the inappropriate level of gamma-aminobutyric acid transporters may be directly or indirectly involved in the pathogenic mechanism underlying certain types of obesity. |
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