| Expression and regulation of IL-22 in the IL-17-producing CD4＋ T lymphocytes |
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| 作者姓名： | Chung Y Yang X Chang SH Ma L Tian Q Dong C |
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| 作者单位： | [1]Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA [2]Institute for Systems Biology, Seattle, WA 98103, USA |
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| 基金项目： | Acknowledgment We thank Bruz Marzolf at the Microarray Facility at Institute for Systems Biology for technical assistance and the entire Dong Lab for discussion and help. This work was in part supported by National Institutes of Health （to CD）. SHC receives a post-doctoral fellowship from the Arthritis foundation and CD is a Cancer Research Institute Investigator and an MD Anderson Cancer Center Trust Fellow. |
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| 摘 要： | IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of tissues against infection. Although CD4＋ helper T lymphocytes （TH） were found as a source of IL-22, the regulation of this cytokine has been poorly understood. Here, we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of TH cells that also makes IL-17. IL-22 and IL-17 were found to be coordinately regulated by TGFI3 and IL-6 during TH differentiation by real-time PCR as well as ELISA analysis. However, IL-22 does not regulate TH differentiation; exogenous IL-22 or an IL-22 antagonist had no effect on TH differentiation. These data demonstrate a novel cytokine expressed by IL-17-producing T cells, and suggest interaction and synergy of IL-22 and IL-l 7 signaling pathways in tissue inflammation and autoimmune diseases.
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| 关 键 词： | IL-22 IL-17 基因表达 T淋巴细胞 |
| 收稿时间： | 2006-09-26 |
| 修稿时间： | 2006-09-262006-10-10 |
Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes |
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| Chung Y,Yang X,Chang SH,Ma L,Tian Q,Dong C.Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes[J].Cell Research,2006,16(11):902-907. |
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| Authors: | Chung Yeonseok Yang Xuexian Chang Seon Hee Ma Li Tian Qiang Dong Chen |
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| Institution: | Yeonseok Chung~1 Xuexian Yang~1 Seon Hee Chang~1 Li Ma~2 Qiang Tian~2 Chen Dong~1 ~1Department of lmmunology,MD Anderson Cancer Center,Houston,TX 77030,USA,~2Institute for Systems Biology,Seattle,WA 98103,USA |
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| Abstract: | IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of tissues against infection. Although CD4+ helper T lymphocytes (TH) were found as a source of IL-22, the regulation of this cytokine has been poorly understood. Here, we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of TH cells that also makes IL-17. IL-22 and IL-17 were found to be coordinately regulated by TGFbeta and IL-6 during TH differentiation by real-time PCR as well as ELISA analysis. However, IL-22 does not regulate TH differentiation; exogenous IL-22 or an IL-22 antagonist had no effect on TH differentiation. These data demonstrate a novel cytokine expressed by IL-17-producing T cells, and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflammation and autoimmune diseases. |
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| Keywords: | cytokines helper T cells T cell activation gene regulation |
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