Contribution of interleukin 1beta and KM loci to alopecia areata |
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Authors: | Galbraith G M Palesch Y Gore E A Pandey J P |
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Institution: | Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425-2230, USA.galbragm@musc.edu |
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Abstract: | Alopecia areata is a common skin disease in which proinflammatory cytokines such as IL-1beta may play a pathogenic role. In this study, we examined the distribution of genotypes of an IL-1beta single base change polymorphism at position +3953 in patients with alopecia areata. The distribution of immunoglobulin kappa light chain (KM) genotypes was similarly examined. The data obtained showed that the IL-1beta and KM loci act cooperatively to significantly increase susceptibility to alopecia areata. |
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