Serum paraoxonase polymorphism in three populations of southeast Asia. |
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| Authors: | A C Roy N Saha J S Tay S S Ratnam |
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| Institution: | Department of Obstetrics and Gynaecology, National University of Singapore. |
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| Abstract: | Serum paraoxonase hydrolyzes paraoxon, the principal metabolite of the insecticide parathion. Serum paraoxonase is polymorphic and controlled by two codominant alleles - PON*A and PON*B representing low and high activity, respectively. Three populations of southeast Asia comprising 194 Chinese, 159 Filipinos and 73 Dravidian Indians were investigated for serum paraoxonase polymorphism. The frequency of PON*B was found to be 0.14 in the Chinese, 0.04 in the Filipinos and 0.18 in Dravidian Indians. The distribution of the PON phenotypes was at Hardy-Weinberg equilibrium in all the three populations studied. |
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