Long non‐coding RNAs in melanoma |
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Authors: | Xin Yu Heyi Zheng Gary Tse Matthew TV Chan William KK Wu |
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Institution: | 1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;2. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Sha Tin, Hong Kong;3. Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Sha Tin, Hong Kong;4. State Key Laboratory of Digestive Disease and LKS Institute of Health Sciences, The Chinese University of Hong Kong, Sha Tin, Hong Kong |
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Abstract: | Melanoma is the most lethal cutaneous cancer with a highly aggressive and metastatic phenotype. While recent genetic and epigenetic studies have shed new insights into the mechanism of melanoma development, the involvement of regulatory non‐coding RNAs remain unclear. Long non‐coding RNAs (lncRNAs) are a group of endogenous non‐protein‐coding RNAs with the capacity to regulate gene expression at multiple levels. Recent evidences have shown that lncRNAs can regulate many cellular processes, such as cell proliferation, differentiation, migration and invasion. In the melanoma, deregulation of a number of lncRNAs, such as HOTAIR, MALAT1, BANCR, ANRIL, SPRY‐IT1 and SAMMSON, have been reported. Our review summarizes the functional role of lncRNAs in melanoma and their potential clinical application for diagnosis, prognostication and treatment. |
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Keywords: | lncRNA prognosis SLNCR1 UCA1 |
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