吸毒人群口腔念珠菌的药物敏感性分析

目的了解吸毒人群口腔念珠菌对常用抗真菌药物的敏感性,为临床治疗念珠菌病提供参考资料。方法采用美国CLSI推荐的微量稀释法测定75株念珠菌对4种常用抗真菌药物两性霉素B、5-氟胞嘧啶、氟康唑和酮康唑的药物敏感性。结果 75株吸毒人群口腔念珠菌对两性霉素B、5-氟胞嘧啶、氟康唑和酮康唑的耐药率分别为0%、4%、8%和13.3%(P0.01),对氟康唑和酮康唑的交叉耐药率为8%;非白念珠菌对氟康唑和酮康唑的耐药率高于白念珠菌(P0.05)。结论吸毒人群口腔念珠菌对两性霉素B和5-氟胞嘧啶的敏感性高于对氟康唑和酮康唑的敏感性。吸毒人群口腔念珠菌存在着对氟康唑、酮康唑和5-氟胞嘧啶的天然耐药株和对唑类药物的天然交叉耐药株,且非白念珠菌对氟康唑和酮康唑的耐药率及交叉耐药率高于白念珠菌。

Analysis on antifungal susceptibility of oral Candida species from drug abusers

Objective To study the antifungal susceptibility of oral Candida from drug abusers and to provide references for clinical treatment of candidosis.Methods Susceptibilities to four common antifungal drugs（fluconazole,ketoconazole,5-flurocytosine and amphotericine B） were determined in 75 isolates of oral Candida by broth microdilution antifungal susceptibility test recommended by CLSI.Results The resistant rates of 75 isolates of oral Candida from drug abusers to Amb,5-FC,FCZ,and KETO were 0%,4%,8%,and 13.3%,respectively（P〈0.01）.The crosswise resistant rates of these strains to FCZ and KETO were 8%.The resistant rate and crosswise resistant rate of non-Candida albicans to FCZ and KETO were higher than those of Candida albicans（P〈0.05）.Conclusions Oral Candida species from drug abusers are resistant to FCZ,KETO and 5-FC in nature,but crosswisely resistant to FCZ and KETO.The resistant and crosswise resistant rates of non-Candida albicans to FCZ and KETO are higher than those of Candida albicans.