| 山苍子油对小鼠系统性新生隐球菌感染的实验研究 |
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| 引用本文： | 万力,李伟,王永强,朱敬山.山苍子油对小鼠系统性新生隐球菌感染的实验研究[J].中国真菌学杂志,2007,2(1):23-26. |
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| 作者姓名： | 万力 李伟 王永强 朱敬山 |
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| 作者单位： | 1. 河北医科大学第四医院皮肤科,石家庄,050011
2. 河北医科大学第四医院药剂科,石家庄,050011 |
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| 摘 要： | 目的研究山苍子油治疗小鼠系统性新生隐球菌感染的疗效。方法建立小鼠系统性新生隐球菌感染模型,观察给药后小鼠的中位生存时间,检测小鼠肾脏及肺菌落形成单位计数。结果山苍子油不仅能够显著延长感染小鼠的中位生存时间,提高其生存率,而且可显著增加感染小鼠肾脏及肺菌落清除率。结论山苍子油对系统性新生隐球菌感染小鼠具有治疗作用。
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| 关 键 词： | 山苍子油 模型 小鼠 新生隐球菌 |
| 文章编号： | 1673-3827（2007）01-0023-04 |
| 收稿时间： | 2006-11-15 |
| 修稿时间： | 2006年11月15 |
Empirical study of Litsea Cubeba oil on systemic Cryptococcus neoformans |
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| WAN Li,LI Wei,WANG Yong-qiang,ZHU Jing-shan.Empirical study of Litsea Cubeba oil on systemic Cryptococcus neoformans[J].Chinese JOurnal of Mycology,2007,2(1):23-26. |
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| Authors: | WAN Li LI Wei WANG Yong-qiang ZHU Jing-shan |
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| Abstract: | Objective To study the therapeutic effect of Litsea Cubeba Oil on the mice infected with Cryptococcus neoformans.Methods The mouse model of disseminated Cryptococcus neoformans was established. Then, the survival rate and median survival time after administrating were detected, Colony counts of kidney and lung were calculated too.Results The results showed that Litsea Cubeba Oil counld apparently prolong median survival time of infected mice, and decrease the colony counts of kidney and lung.Conclusion Litsea Cubeba Oil has therapeutic effects on disseminated Cryptococcus neoformans of mice. |
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| Keywords: | Litsea Cubeba oil models mice Cryptococcus neoformans |
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