Two-way communication between the metabolic and cell cycle machineries: the molecular basis |
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Authors: | Joanna Kaplon Loes van Dam Daniel Peeper |
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Institution: | 1.Division of Molecular Oncology; The Netherlands Cancer Institute; Amsterdam; The Netherlands;2.Department Molecular Cancer Research; Division of Biomedical Genetics; University Medical Center Utrecht; Utrecht, The Netherlands |
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Abstract: | The relationship between cellular metabolism and the cell cycle machinery is by no means unidirectional. The ability of a cell to enter the cell cycle critically depends on the availability of metabolites. Conversely, the cell cycle machinery commits to regulating metabolic networks in order to support cell survival and proliferation. In this review, we will give an account of how the cell cycle machinery and metabolism are interconnected. Acquiring information on how communication takes place among metabolic signaling networks and the cell cycle controllers is crucial to increase our understanding of the deregulation thereof in disease, including cancer. |
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Keywords: | cell cycle cyclin-dependent kinases glycolysis metabolism nutrients proliferation |
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