乙肝病毒家庭内传播情况调查

乙型肝炎病毒感染是全球性的健康问题,其传播途径各个国家及地区存在差异.通过对543位慢性HBV感染者的调查分析,家庭中女性慢性HBV感染者其子女在无任何免疫预防干预下感染后慢性化的几率76.0%;男性慢性HBV感染者其子女感染HBV后慢性化的几率达22.5%;夫妻之间HBV感染的结局是以形成保护性抗体为主,调查的543对夫妻中,夫妻双方均为HBsAg阳性的有50对,达9.2%;HBV在夫妻之间的传播的特点是丈夫感染HBV后更容易慢性化:妻子为慢性HBV感染者,其丈夫被感染后慢性化的几率为13.8%(27/196);而丈夫为慢性HBV感染者的家庭中,其妻子被感染后慢性化的几率为7.1%(23/322),差异具有统计学意义(χ2=6.146,P=0.013);除母婴传播外,乙肝病毒在夫妻、父亲和子女、孩子之间以及其他家庭接触性传播也很重要.

Transmission of Hepatitis B Virus Among Family Members and Effects of Immunoprophylaxis on Offspring of Chronic Carriers

Hepatitis B virus(HBV) infection remains a serious global health problem.The transmission route of HBV may different among countries.543 chronic HBV carriers were investigated,HBsAg positivity among offspring from female carriers was 76.0% and 22.5% from that of male carriers.Most of the infection be-tween husbands and wives resulted in generation of protective antibody.50 out of 543 couples(9.2%) were both positive on HBsAg.Husbands were more susceptible to becoming chronic carriers than wives when in-fected by their spouses.The prevalence of chronic infection in husbands of infected wives was 13.8%,while that in wives of infected husbands was 7.1%(χ2=6.146,P=0.013).Horizontal transmission among family members is also important,such as the relationship between husband-wife,father-child,child-child,as well as other household contacts.