基于混沌游走方法的Rh血型系统中RHD基因的分析

利用基于经典HP模型的蛋白质序列混沌游走方法（chaos game representation，CGR），给出了RHD基因的蛋白质序列CGR图，可视作蛋白质序列二级结构的一个特征图谱描述．对临床上的血型鉴别有一定的参考价值．另外．还根据由Jeffrey在1990年提出的描绘DNA序列的CGR方法，给出了RHD基因的DNA序列的CGR图．并且根据RHD基因DNA序列的CGR图算出了尺日D基因相应的马尔可夫两步转移概率矩阵，从概率矩阵表可以看出RHD基因对编码氨基酸的三联子的第3个碱基的使用偏好性．

Analysis of RHD Gene by Chaos Game Representation

By using the chaos game representation (CGR) method of protein sequences based on the detained HP model, the CGR graph of the protein sequences of RHD gene were given, and some characters of the protein's secondary structure of RHD gene were obtained. At the same time, according to the CGR of the DNA sequences proposed by Jeffrey in 1990, the CGR graph of the DNA sequences of RHD gene were given and the corresponding probability matrix for the second-order Markov Chain model were obtained. Furthermore, from the probability matrix, the usage preference that the third base of the codons in the DNA sequence of the RHD gene were educed.