NO-1886改善糖尿病小型猪的糖代谢

合成化合物NO-1886是一种脂蛋白脂酶活化剂，已被证明其可降低血浆TG并能升高HDLC的浓度．后又发现其还有降低高脂高蔗糖诱发糖尿病兔血浆葡萄糖浓度的作用．对高脂高蔗糖饲料喂养的小型猪脂肪细胞大小、血浆TNF—α和FFA的水平以及NO-1886对其影响进行了研究，结果发现，脂肪细胞明显肥大．血浆TNF-α和FFA以及空腹血糖水平均增高，且引起胰岛素抵抗．添加了l％NO-1886后．脂肪细胞增大被抑制，血浆TNF—α、FFA和空腹血糖的浓度均显著降低，血浆葡萄糖清除率和胰岛素分泌急性相都有了明显改善．以上结果说明，NO-1886可能通过抑制脂肪蓄积、降低血浆TNF-α和FFA的浓度而改善高脂高蔗糖饲料引起的小型猪的糖代谢紊乱．

NO-1886 Improves Glucose Metabolism in Diabetes Minipigs

The synthetic compound NO-1886 is a lipoprotein lipase activator that has been proven to be highly effective in lowering plasma triglycerides and elevating high-density lipoprotein cholesterol. It was found that NO-1886also had a plasma glucose - reducing action in high - fat / high - sucrose diet - induced diabetic rabbits. In the current study, the effects of NO-1886 on the morphology of adipocytes, plasma levels of tumor necrosis factor-α (TNF-α)and free fatty acids (FFA) in miniature pigs fed a high fat/high sucrose diet was investigated. The results showed that feeding a high-fat/high-sucrose diet to miniature pigs increased the size of adipocytes, and the plasma levels of TNF-α, FFA, and glucose. This diet also induced insulin resistance and impaired the acute insulin response to glucose loading. Supplementing 1％ NO-1886 to the high-fat/high-sucrose diet inhibited adipocyte enlargement, and suppressed plasma levels of TNF-α, FFA, and glucose. The decrease in plasma TNF-α and FFA was simultaneous with the decrease in plasma glucose. It was also found an increased whole body glucose clearance and an increased acute insulin response to intravenous glucose loading by NO-1886 supplementation. These data suggest that NO-1886 improves the glucose metabolism in high fat/high sucrose diet-induced diabetic minipigs by decreasing fat deposit, and suppressing plasma TNF-α and FFA levels. Therefore, NO-1886 is potentially beneficial for the treatment of insulin resistant syndrome.