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多马胺能药物对鲇鱼促性腺激素(GtH)分泌活动的影响
引用本文:温海深,林浩然.多马胺能药物对鲇鱼促性腺激素(GtH)分泌活动的影响[J].生命科学研究,2001,5(1):84-87.
作者姓名:温海深  林浩然
作者单位:中山大学 水生经济动物研究所,
基金项目:国家自然科学基金资助项目(39970586)
摘    要:以珠江流域鲇鱼(silurus asotus)为实验材料,研究了多巴胺(DA)能药物(DA及其D-2型受体拮抗物 ,DOM)对鲇鱼促性腺激素(GtH)释放的影响,结果表明,在性腺发育的各个时期,单独注射DOM(5ug/g)均不能显著提高鲇鱼血液基础GtH水平,当DOM与LHRH-A联合注射时能显著增强LHRH-A刺激GtH释放的作用;DA只能抑制GnRH诱导的GtH释放,对基础GtH释放无抑制作用,这种生殖内分泌调节方式与鲇形目的革胡子鲇(Clarias gariepinus)和大鳍Hu(Mystus macropterus)相似,而与鲤形目的鲁科(Cyrpindiae)鱼类不同。

关 键 词:鲇鱼  促性腺激素  多巴胺  地欧酮  内分泌调节
文章编号:1007-7847(2001)01-0084-04
修稿时间:2000年11月16

Effects of Dopaminergic Drugs on Gonadotropin Release of Feral Catfish(Silurus asotus)
WEN Hai-shen,LIN Hao-Ran.Effects of Dopaminergic Drugs on Gonadotropin Release of Feral Catfish(Silurus asotus)[J].Life Science Research,2001,5(1):84-87.
Authors:WEN Hai-shen  LIN Hao-Ran
Abstract:The effects of dopamine (DA) and domperidone (DOM), a dopamine D 2 receptor antagonist, on gonadotropin (GtH) release in catfish ( Silurus asotus ) were investigated. DOM failed to stimulate an increase in basal level of serum GtH in different stages of ovarian development, injection of DOM plus LHRH A resulted in significantly higher serum GtH level than control groups.DA failed to inhibit the basal level of serum GtH, but blocked GtH release induced by GnRH. These results suggested that the neuroendocrine regulation of GtH release in catfish is different from goldfish ( Carassius auratu ) and common carp ( Cyprinus carpio ), but similar to that of African catfish ( Clarias gariepinus ) and bagrid catfish ( Mystus macropterus ).
Keywords:catfish(  Silurus asotus  )  gonadotropin (GtH)  dopamine (DA)  domperidone (DOM)
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