Antibacterial activity of rufloxacin in theStaphylococcus aureus rat granuloma pouch model |
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| Authors: | Giuseppe Ravizzola Gabriele Pinsi Marina Cesana Carmela De Rango Laura Peroni Prof Adolfo Turano |
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| Institution: | (1) Institute of Microbiology, University of Brescia, Spedali Civili, 25100 Brescia, Italy;(2) Medical Department, Mediolanum Pharmaceuticals, Milano, Italy |
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| Abstract: | The protective effects of rufloxacin againstStaphylococcus aureus-induced infections were compared with those of ciprofloxacin in the granuloma pouch model in the rat. Two strains with different in vitro sensitivity to the drugs were studied. Rufloxacin concentrations persisted longer than ciprofloxacin in the exudate in the pouch cavity and were about eight times higher. Equal doses of rufloxacin and ciprofloxacin had similar antibacterial activities. However, rufloxacin inhibitedStaphylococcus aureus bacterial growth significantly longer than did ciprofloxacin. |
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