Differentiation antigens of hemoblastoses and epithelial tumors: Relations to the mechanisms of transformation and progression |
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| Authors: | G I Abelev |
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| Institution: | (1) Institute of Carcinogenesis, Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 24, Moscow, 115478, Russia |
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| Abstract: | The role of mechanisms underlying differentiation is considered in malignant transformation of hemoblastoses and epithelial tumors. In hemoblastoses, differentiation is intimately related to malignant transformation and they are underlain by the same mechanisms. Immunophenotyping of hemoblastoses is fully based on successive stages of their differentiation with characteristic expression of differentiation antigens. Unlike hemoblastoses, epithelial tumors gradually, in the course of progression, lose their differentiation due to the degradation of the connections with the microenvironment, which controls the direction and level of epithelial differentiation. Therefore, carcinomas are characterized by varying degrees of “antigenic simplification”, including the epithelial-mesenchymal transition. |
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| Keywords: | differentiation of hemoblastoses differentiation of epithelial neoplasms immunophenotyping of hemoblastoses antigenic simplification of carcinomas progression and differentiation of tumors tumor markers epithelial-mesenchymal transition role of microenvironment in tumor progression |
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