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Comparative Characteristics of Immunological,Clinical and Morphological Features of Human Lymphoid Tumors in Respect with Tumor Genesis and Progression
Authors:Gretsov  E M  Churakova  J V  Sheval  E V  Vorobjev  I A
Institution:(1) Hematological Research Center of the, Russian Academy of Medical Sciences, Novozykovskii pr. 4a, Moscow, 125167, Russia
Abstract:We describe three lymphoid tumors with the same immunophenotype characteristic for chronic lymphoid leukemia (CD19+/CD5+, clonality of the light immunoglobulin chains, CD23+ and CD10). However, clinical picture and morphology of neoplastic cells dictate different clinical forms of these cases: chronic lymphoid leukemia, large cell transformation of chronic lymphoid leukemia and diffuse large B-cell lymphoma. Taking into account that immunophenotype reflects the origin of tumor, while clinical outcome and morphological features of cells reflect the stage of tumor progression and/or pathway of tumor formation, we discuss the approach to natural classification of lymphoid tumors based on the process of their evolution.
Keywords:lymphoid tumor  oncogenesis  tumor progression  systematics  immunophenotype  cell morphology
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