Prevention of doxorubicin-induced cardiotoxicity by recombinant interleukin-1 in hamsters |
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| Authors: | Takashi Yoshida Hirokazu Okumura Hiroyasu Kaya Yoko Okabe Sadaya Matano Shigeki Ohtake Shinobu Nakamura Tamotsu Matsuda |
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| Institution: | (1) The Department of Internal Medicine, Toyama Perefectural Central Hospital, Toyama, Japan;(2) The Third Department of Internal Medicine, Kanazawa University, School of Medicine, Kanazawa, Japan |
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| Abstract: | The major factor contributing to doxorubicin (DXR)-induced cardiotoxicity is the insufficiency of antioxidant defense mechanisms. As a model of acute cardiotoxicity with DXR, ten-week-old golden hamsters were given DXR (5 mg/kg) intravenously, and the toxicity was investigated by monitoring ECG changes. Complete A-V block and cardiac arrest on the ECG were observed in DXR-treated hamsters. DXR-induced edema and fragmentation of myofibrils were observed by electron-micrograph. Pretreatment with interleukin-1 (10 or 1 g/body) 12 or 24 hrs before prevented these changes, but pretreatment with tumor necrosis factor had no effect.Abbreviations DXR
doxorubicin
- IL-1
interleukin-1
- Mn SOD
manganous superoxide dismutase
- TNF
tumor necrosis factor |
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| Keywords: | Interleukin-1 doxorubicin cardiotoxicity tumor necrosis factor and Superoxide dismutase |
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